NLRP3 and small cell lung carcinoma: RRx-001 is a minimally toxic NLRP3 inhibitor (15, 16) in Phase 3 for small cell lung cancer (SCLC) (17) that is associated with vascular normalization (18) properties as well as epigenetic inhibition and tumor associated macrophage repolarization through CD47 downregulation (19, 20).