CD8A and neoplasm: One strategy that has been tried to increase the cytotoxic activity of CD8 T cells and to overcome the immunosuppressiveness of the tumor microenvironment is the administration of immunotherapy in combination: checkpoint inhibitors with non-overlapping mechanisms of action such as an anti-PD-1 and an anti-CTLA-4 have been evaluated in several tumor types (4), which increased response rates but also the frequency and severity of immune related adverse events (5, 6).