However, in that report, during LCMV infection the loss of SHP2 resulted in enhanced expansion (almost 3 fold) of virus-specific effector CD8+ T cells and in a tumor model the ability of PD-1 blockade to enhance the percentage of total and IFNγ positive intra-tumoral CD8+ T cells was SHP2-dependent. The gene discussed is CD8A; the disease is neoplasm.