PIDs with HPV clinical implications include epidermodysplasia verruciformis (EV), WHIM (warts, hypogammaglobulinemia, infections and myelokathexis) syndrome, DOCK8 mutations, GATA binding protein 2 (GATA2) mutations, and severe combined immunodeficiency (SCID) (103, 104). The gene discussed is DOCK8; the disease is epidermodysplasia verruciformis.