DKK3 and infection: Moreover, siRNA silencing of Wnt signaling components, including β-catenin, CK1, Fzd5, Fzd9, and LRP6, significantly decreases E. chaffeensis infection, while silencing Wnt antagonist Dickkopf-related protein 3 (DKK3) promotes infection (Luo et al., 2016).