Factors leading to Pt resistance are various, including angiogenesis, hypoxia, immune infiltration, and abnormal regulation of breast cancer susceptibility gene (BRCA), ATP binding cassette subfamily B member 1 (ABCB1) and cyclin E1 (CCNE1), etc. (Pennington and Swisher, 2012; Patch et al., 2015). The gene discussed is CCNE1; the disease is cancer.