APLNR and neoplasm: APLN/APLNR signaling has been demonstrated to associate with neovascularization, tumor vessel density, microvascular proliferation, and tumor growth in other types of tumors (Sorli et al., 2006; Kalin et al., 2007; Sorli et al., 2007; Berta et al., 2010; Wu et al., 2017).