Then the classic fibrotic pathway MAPK activated, the level of phosphorylation of p38, ERK and JNK increased in adenine-induced renal fibrosis animal model (Rhyu et al., 2012; Tang et al., 2021; Zhou et al., 2021; Ha et al., 2022; Kim et al., 2022). Here, MAPK8 is linked to renal fibrosis.