In addition, in HLA class II positive cHL cases, HLA-DM expression is lost in around a half of patients, leading to a functional loss of HLA class II, as HLA-DM is required to displace the class II invariant chain peptide and allow antigen loading into HLA class II (Nijland et al., 2017). The gene discussed is HLA-DMA; the disease is classic Hodgkin lymphoma.