Stronati et al. (2010) also found an elevation of RIPK2 level in the colonic mucosa of UC patients, which involved both gene and protein expression. In a recent study, Watanabe et al. (2019) used plasmids expressing a RIPK2-specific siRNA to reduce disease severity in trinitrobenzene sulfonic acid (TNBS) induced colitis in mice. The gene discussed is RIPK2; the disease is colitis.