IFNG and Behcet disease: IFN-γ and IL-12 from Th1 cells can mediate the inflammatory response of T cells and neutrophils, while IL-17 from TH17 cells can make the neutrophils hyper reactive in patients with BD (Kim et al., 2010; de Chambrun et al., 2012; Emmi et al., 2016; Nanke, Yago, and Kotake, 2017; Lucherini et al., 2018; Tong et al., 2019; van der Houwen, van Hagen, and van Laar, 2022).