Rahman et al. (2019) identified two siblings affected with ID who are both impacted by large terminal duplication (18.82 Mb) and deletion (3.90 Mb) CNVs. The remaining eight patients carried different lengths of deletion and duplication CNVs that disrupt the vital regions of the chromosome containing bona fide genes (SCN1A, KANK1, DOCK8, etc.) associated with different types of neurodevelopmental disorders (Nassir et al., 2021) (Table 1). The gene discussed is DOCK8; the disease is neurodevelopmental disorder.