CA2 and osteopetrosis: Three other unrelated patients (#13, #15, and #207) carried 48 Kb duplication at 15q13.3, which disrupts the previously reported (Gillentine and Schaaf, 2015; Gillentine et al., 2017; Uddin M. et al., 2018) broader NDD genes CHRNA7 and OTUD7A. We found a 381-Kb duplication in two unrelated ASD patients (#34 and #104) at 8q21.2, disrupting carbonic anhydrases II (CA2), a gene associated with the disease osteopetrosis, autosomal recessive 3, OPTB3 (OMIM# 259730).