Down’s syndrome; C21orf59, SON, HLCS, KCNE1, DYRK1A, C21orf2, COL18A1, PCNT, RSPH1, RIPK4, CBS, FTCD, SIK1, COL18A1, CRYAA, AIRE, and CSTB. This evidence concerns the gene DYRK1A and Down syndrome.