Furthermore, various cell lines derived from cancers such as P493-6 B-cell lymphoma, PC3 prostate cancer (171), osteosarcoma (172), Ramos and Raji B-cell lymphoma (173), renal cell carcinoma (174), HCT116 CRC (175), and U-1906 small cell lung carcinoma (176) cells rely on glutamine for cellular survival and growth under MYC activation. The gene discussed is MYC; the disease is osteosarcoma.