Recent studies show that elevated ratios of aspartate to alanine transaminases (AST/ALT or GOT/GPT) correlate with a poor prognosis in bladder (144), colorectal (145), hepatic (146), head and neck (147), oral and oropharyngeal (148), prostate (149), and pancreatic (150) cancers. The gene discussed is GPT; the disease is cancer.