Recent studies show that elevated ratios of aspartate to alanine transaminases (AST/ALT or GOT/GPT) correlate with a poor prognosis in bladder (144), colorectal (145), hepatic (146), head and neck (147), oral and oropharyngeal (148), prostate (149), and pancreatic (150) cancers. This evidence concerns the gene GOT1 and cancer.