(39) utilized a 354-gene NGS panel to profile the genomic landscape of ctDNA from 26 HCC patients and found a positive ctDNA detection rate of 96.2%, wherein TP53 (50.00%) was the most common mutant gene, followed by AXIN1 (11.54%), BCOR (11.54%), CTNNB1 (11.54%), FANCE (11.54%), FANCM (11.54%), and NCOR1 (11.54%). Here, TP53 is linked to hepatocellular carcinoma.