To further assess the role of DEG in LUAD, we used the GEPIA online database (http://gepia.cancer-pku.cn) to analyze the expression levels of CD274, TIGIT, PDCD1, CTLA4 and LAG3 in normal population and tumor tissues of LUAD patients, as well as the relationship between each gene and LUAD patients. Here, TIGIT is linked to neoplasm.