NE-like cells are called so because they exhibit NE characteristics such as long neurite outgrowths and express NE markers including synaptophysin (SYN), chromogranin A (CgA), neuron-specific enolase (NSE) etc. These NE-like prostate cancer cells are usually resistant to existing treatments and correlates to poor prognosis (13). Here, ENO2 is linked to Familial prostate cancer.