CREBBP and acute lymphoblastic leukemia: In the case of BCP-ALL, a potential exemplar of this are loss of function mutations in the transcriptional co-activator CREBBP. CREBBP deletion, or point mutations affecting its enzymatic acetyltransferase domain, are enriched in relapsed BCP-ALL (6) and high-risk genetic subtypes such as near-haploid BCP-ALL (85).