• ZEB1-regulated overexpression of ZIP4 reduces the expression of ZO-1 and claudin-1, leading to the phosphorylation of FAK and Paxillin, thus promoting PCa invasion and migration• 5-HT1B, 5-HT1D, and eEF2K/MAPK-Erk pathway. Here, PTK2 is linked to posterior cortical atrophy.