ZNF460-regulated LINC00857 upregulates claudin-12 expression by sponging miR-1505p and recruiting SRSF1 to promote PAAD cell progression (53).Interleukin (IL)-18 is important in inducing BC cell migration via the downregulation of claudin-12 (52). Here, CLDN12 is linked to pancreatic adenocarcinoma.