Long intergenic non-coding RNAs (LNC00857) was found to affect the phenotype of PAAD cells by targeting miR-150-5p to regulate claudin-12 expression and by recruiting serine/arginine-rich splicing factor 1 (SRSF1) to promote selective splicing (AS) targeting claudin-12. The gene discussed is CLDN12; the disease is pancreatic adenocarcinoma.