CLDN4 and posterior cortical atrophy: Histopathological examination revealed that the incidence of lymphovascular (ly), vascular (v), and neural (ne) invasion was higher in the low claudin-4 expression group than in the high claudin-4 protein expression group (P = 0.0014, 0.0133, and 0.0205, respectively) and overexpression of epithelial claudin-4 reduced the invasive and metastatic potential of the PCa cells in vitro (75).