found that the dissociation factors (DFs) isolated from the medium of highly invasive and metastatic PC-1.0 PCa cells induced dissociation of weakly invasive and migratory PCa cells (PC-1), and the addition of DF-conditioned medium significantly reduced CLDN23 mRNA and protein expression in PC-1 cells. This evidence concerns the gene CLDN23 and posterior cortical atrophy.