There is a synchronization between insulin levels and melatonin during the night and day, in which melatonin action is inhibited by insulin release (and reduce glucose tolerance) through its membrane receptors MT1 and MT2, and the secondary messengers 3′,5′-cyclic adenosine monophosphate, 3’,5’-cyclic guanosine monophosphate, and inositol 1,4,5-trisphosphate [6]. Here, INS is linked to glucose measurement.