The results showed that 9 of the 10 co-expressed genes, including ITGA5, SLC2A3, ELL2, ABL2, SLC2A14, XIRP1, SHC1, CEBPB, and ADA, were significantly upregulated in ccRCC tissues (Fig. 7A–J). Here, SHC1 is linked to nonpapillary renal cell carcinoma.