Methylation of members of this gene family have been associated with a number of phenotypes, including EBF4 methylation associated with hematopoiesis and neuronal development in persons with Trisomy 21 [64], and EBF1 and EBF3 methylation to neurobehavioral development in very preterm infants [65]. This evidence concerns the gene EBF1 and trisomy 21.