SORT1 was associated with the mTOR signaling pathway (NES = 1.9278517, NOM p < 0.001, FDR = 0.021522397), pathways in cancer (NES = 1.9270834, NOM p < 0.001, FDR = 0.018652743), VEGF signaling pathway (NES = 1.916239, NOM p < 0.001, FDR = 0.017952878), lysosome (NES = 1.9507663, NOM p < 0.001, FDR = 0.026280008), and neurotrophin signaling pathway (NES = 1.9135792, NOM p < 0.001, FDR = 0.017722571) (Fig. 7D). The gene discussed is BDNF; the disease is cancer.