It is thought to be a Th1 dominated disease primarily because IFN-γ, IL-12, IL-18, TNF-α, IL-1b, IL-6 and B-cell activating factor (BAFF) are consistently found to be highly expressed in SS patients [15] Otherwise Th2-related cytokines had been also found elevating at the mRNA and (or) protein level in the majority of labial salivary glands (LSG) of patients with SS, such as IL-13 and IL-4 [16, 17]. This evidence concerns the gene IFNG and synovial sarcoma.