As expected, PES1 knockdown dramatically enhanced the infiltration of CD8+ CTL in AKR subcutaneous tumors (Fig. 2E, F) and also increased the percentages of GZMB+/CD8+ CTL, a marker of activated CD8+ CTL, in tumor microenvironment compared to SCR group (Fig. 2G). The gene discussed is GZMB; the disease is neoplasm.