The hypothesis of this study is that complementing EBRT and ADT with a single cycle concurrent [177Lu]Lu-PSMA-617 is safe, while providing synergistic anti-tumour effects with limited toxicity and without prolonging overall treatment time, with potential to improve tumour control and quality of life for future patients with N1M0 prostate cancer. This evidence concerns the gene FOLH1 and Familial prostate cancer.