Considering that the tumor DNA sequences belonging to the APC gene comprised of \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\approx$$\end{document}≈ 64% of the data before SMOTE sampling, the machine learning models classified most sequences as positive (tumor); with the CNN achieving the best overall with the highest accuracy of 67.3 ± 0.04%. Here, APC is linked to neoplasm.