The molecular mechanisms involved in the alcohol-induced fatty liver include crosstalk between the upregulation of SREBP-1c, ACC-1, and FASN and the downregulation of PPARα (Ji et al. 2006; Meng et al. 2020; Wang et al. 2021c), which was evident in our reported data in the ALD group. This evidence concerns the gene SREBF1 and fatty liver disease.