Despite lower peripheral insulin sensitivity at baseline (p < 0.0001, data not shown), participants with T2D had greater improvements in insulin-stimulated Rd at 2, 12, and 52 weeks compared to participants without T2D (p = 0.007, p = 0.0006 and p = 0.02, respectively, data not shown). This evidence concerns the gene INS and type 2 diabetes mellitus.