The WSDL model was developed using (i) our previously validated panel of seven markers (PD-L1, PD-1, CD8, CD68, FOXP3, CK, and DAPI)22, (ii) NaroNet, designed to extract the complex tumor-immune interrelations at multilevel features (local phenotypes, cellular neighborhoods, and tissue areas) using unsorted multiplexed IF images (in the current approach, no images were excluded from the analyses, while previously only images with a minimum tumor content of 20% were analyzed), and (iii) a tenfold cross-validation approach (in our previous approach, all samples were used to train the model). The gene discussed is CD8A; the disease is neoplasm.