The diminished therapeutic effects of combination treatment in these mouse models suggest that STING activation in the host immune system, rather than tumor itself, is the major mechanism of the treatment effects, and that the TAMC reprogramming-mediated antitumor functions of adaptive immunity, especially CD8+ T cells, play an important role in the treatment effects, which are strongly supported by our in vivo scRNA-seq data. This evidence concerns the gene CD8A and neoplasm.