CCR2 and central nervous system cancer: In addition, strengthened T cell-glioma interactions through chemokine signaling, such as CCR5-CCL7/CCL8, CCR2-CCL7/CCL8/CCL11, CXCR3-CXCL9/CCL19, and CXCR6-CXCL16, were also revealed by a ligand-receptor analysis (Supplementary Fig. 9b).