Similar to the results of intracranial administration, a regimen combining fractionated RT with intravenously injected P-LNP/diABZI, but not free drugs, led to enhanced CD8+ T cell tumor infiltration (Supplementary Fig. 19) and animal survival in CT-2A glioma model, eradicating engrafted tumor from 70% of the glioma-bearing mice (Fig. 9a). Here, CD8A is linked to neoplasm.