The facts that increased T cell infiltration and activation were observed in glioma-bearing mice post-B-LNP/diABZI treatment, while neither free drug combinations nor drug-free B-LNP were able to show the same potency, highlight the importance of B-LNP-mediated coordinate modulation of multiple TAMC antitumor mechanisms over solely promoting phagocytosis or activating STING pathways. Here, STING1 is linked to central nervous system cancer.