Nonetheless, several lines of evidence have demonstrated that TGF-β signaling is dysregulated in leukemia.33,34 Here, we report that insensitivity to TGF-β in CML comes from the BCR-ABL1 oncoprotein that disrupts the homeostatic function of TGF-β signaling. This evidence concerns the gene TGFB1 and chronic myelogenous leukemia, BCR-ABL1 positive.