The microtubule-associated protein tau deposits into β-sheet-rich amyloids in over 25 neurodegenerative diseases commonly referred to as tauopathies that include Alzheimer’s disease (AD), Corticobasal degeneration (CBD), Picks disease (PiD), and Chronic traumatic encephalopathy (CTE)1–3. The gene discussed is MAPT; the disease is Alzheimer disease.