Automated DeepSNiF denoising reveals that as disease develops, the B cell distances become larger (P < 0.01); The distances between CD4 T and B cells in normal and MDS tissues are greater than those of AML (P < 0.0001); And CD4 and CD8 T cells in normal tissues trend towards longer distances than those in MDS (P = 0.0916). Here, CD4 is linked to myelodysplastic syndrome.