NUP98-PMX1;Abl1−/− murine leukemia cells were highly sensitive to buparlisib when compared to NUP98-PMX1;Abl1 + /+ counterparts (Fig. 3F, left panel), at the same time ABL1 did not affect the sensitivity of AML1-ETO cells to the inhibitor (Fig. 3G, left panel). The gene discussed is RUNX1; the disease is leukemia.