,3,4,5 The application of DL for such complex tasks represents a major part of “computational pathology.”3,4,6 In colorectal cancer (CRC), DL-based predictability of biomarkers from H&E-stained tissue sections has been reported for microsatellite instability (MSI)7,8,9,10,11,12,13,14 and, in smaller studies, for mutations in BRAF,10,13TP53, KRAS, SMAD4, PIK3CA, and other genes.4 This evidence concerns the gene PIK3CA and colorectal carcinoma.