KRAS and colorectal cancer: ,3,4,5 The application of DL for such complex tasks represents a major part of “computational pathology.”3,4,6 In colorectal cancer (CRC), DL-based predictability of biomarkers from H&E-stained tissue sections has been reported for microsatellite instability (MSI)7,8,9,10,11,12,13,14 and, in smaller studies, for mutations in BRAF,10,13TP53, KRAS, SMAD4, PIK3CA, and other genes.4