The top 10 hub genes in stroke-DEGs included G protein subunit gamma transducin 1 (GNGT1, degree = 18), phospholipase C gamma 1 (PLCG1, degree = 15), platelet factor 4 (PF4, degree = 15), AKT serine/threonine kinase 1 (AKT1, degree = 14), gamma-glutamyl hydrolase (GGH, degree = 13), catenin beta 1 (CTNNB1, degree = 13), junction plakoglobin (JUP, degree = 11), major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1, degree = 11), LCK proto-oncogene (LCK, degree = 11), and adenylate cyclase 4 (ADCY4, degree = 11). The gene discussed is PLCG1; the disease is Stroke.