Furthermore, NOD2 polymorphisms have been associated with preterm birth in several genetic studies examining innate immunity, preterm premature rupture of membranes (PPROM), and early onset PE and HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) syndromes [62, 67, 70, 71]. The gene discussed is NOD2; the disease is preterm premature rupture of the membranes.