KLK3 and Familial prostate cancer: In the case of PSA in prostate cancer, a simple model (Hirata et al., 2010), a more complex model with basic androgen dynamics (Portz et al., 2012), and a detailed model of androgen dynamics (Jain et al., 2011) all fit data on a set of patients reasonably well, although with some exceptions (Hatano et al., 2015).