Tumor growth and metastasis were monitored by evaluating the resulting bioluminescence values, which along with examination of lungs revealed that the RCN2 knockout group formed fewer pulmonary metastatic foci than the control group, with many more lung metastatic foci of overexpressed RCN2 cells than those of the negative control (Fig. 4F-H). Here, RCN2 is linked to neoplasm.