Presence of TGFBR3L was associated with a higher IRS of LHβ in gonadotroph NF-PitNETs (median 2 [IQR 0–3]) in TGFBR3L negative and median 6 [IQR 3–9]) in TGFBR3L positive tumours, p < 0.001). The gene discussed is LHB; the disease is neoplasm.