PLN and Arrhythmia: In contrast, we explain in a previous study that there is an increased basal incidence of arrhythmias at 37 °C in H2-TG mice under basal conditions and normothermia, which is induced by an elevated basal generation of cAMP that subsequently increases the phosphorylation state of PLB (Fig. 1A) (Gergs et al. 2021c).