We analyzed the TME and spleen for levels and activation of macrophages and dendritic cells on the same days as described in Figure 3A. We observed an increase in both CD11b+Gr1– macrophages and CD11c+MHC-II+ dendritic cells of live CD45+ cells in tumor-bearing livers of mice treated with mIL-18–secreting CAR T cells, compared with CAR T cells without mIL-18 (Figure 4A). Here, ITGAM is linked to neoplasm.