OGT and cancer: Connections between OGT and ERK have also been uncovered in the context of cancer and cell division, with studies showing that inhibition of ERK signaling decreases O-GlcNAcylation and vice versa (Zhang et al., 2015; Jiang et al., 2016) and that GlcNAcylation promotes ERK effects while OGT inhibition blocks them (Cork et al., 2018; Weiss et al., 2021; Lei et al., 2020).