Urolithin B inhibits the proliferation and the growth of hepatocellular carcinoma cells and induces cell cycle arrest and apoptosis of these cancer cells by inactivating the Wnt/β‐catenin signaling pathway.[90] p53 is a well‐known tumor suppressor protein, and mutations in p53 that inactivate its tumor‐suppressor function promote carcinogenesis.[91, 92] However, mutant versions of p53 were shown to possess tumor‐suppressive effects in the proximal gut and tumor organoids. The gene discussed is TP53; the disease is hepatocellular carcinoma.