CXCR1 and malignant colon neoplasm: On the one hand, it stimulates the secretion of IL‐8 by colon cancer cells and consequently plays a role in promoting colon cancer progression.[23] The TME of colon cancer cells is always characterized by high levels of IL‐8 and its associated receptors, C‐X‐C motif chemokine receptor 1 (CXCR1) and CXCR2.