RAC1 and cancer: UA reduces Rac1 activity and the phosphorylation of PAK1 inhibiting cancer.[101] In addition, ellagic acid and its metabolite UA have the potential to prevent the progression of colon cancer and liver cancer because they regulate the nuclear factor erythroid 2‐related factor 2 (Nrf2) signaling pathway to reduce oxidative stress‐induced inflammatory injury in the intestine and liver.[102, 103] Hippo/yes‐associated protein (YAP) signaling is another signaling pathway that promotes cancer progression.