PIK3CA and cancer: These effects are mediated through inhibition of the phosphorylation of Akt and p70 ribosomal S6 protein kinase (p70S6K).[80] Through the same mechanism, UA attenuates the inflammatory responses in patients with alcoholic chronic pancreatitis.[81] Phosphatase and tensin homolog, a well‐known phosphatase, interferes with the function of PI3K preventing cancer progression.