NLRP6 and colitis: The derivative 3‐oxoLCA inhibits the differentiation of Th17 cells by binding to transcription factor retinoid‐related orphan receptor γt (RORγt) directly, while isoalloLCA inhibits colitis by promoting the differentiation of Treg cells.[59] Patients with colitis have a high chance of developing colon cancer.[60] Microbial metabolite taurine regulates the inflammasome NOD‐like receptor family pyrin domain containing 6 (NLRP6) in intestinal epithelial cells ameliorating colitis, conversely, histamine exacerbates colitis.[61, 62]