Gallic acid, another metabolite of the gut microbiota, switches mutant p53 from tumor‐suppressive to oncogenic.[93] Butyrate induces lysosomal‐dependent autophagy in colon cancer cells harboring a mutation in APC or β‐catenin, which disrupts the Wnt signaling.[94] Gut microbial metabolite isovalerate enhances the release of 5‐hydroxytryptamine from enteric serotonergic neurons, which can enhance the interaction between axin and the 5‐hydroxytryptamine receptor 1B in colorectal cancer stem cells. Here, TP53 is linked to neoplasm.