ADORA2A and neoplasm: It directly inhibits ubiquitin‐like modifier activating enzyme 6 in tumor cells, thus endowing tumor cells with stronger immunogenicity and increasing the ability of T cells to kill tumors.[155] In addition, inosine binds to A2AR in the existence of exogenous IFN‐γ and promotes Th1 differentiation through cyclic adenosine monophosphate/protein kinase A signaling.