IL10 and colonic neoplasm: Th17 cells promote while Tregs inhibit chronic inflammation and exacerbation of inflammatory diseases.[38, 39] IL‐10 prompts the phosphorylation of STAT3 in Tregs and endows them with the capacity of suppressing Th17 cell‐mediated inflammation.[40] Therefore, butyrate suppresses colonic inflammation and hinders colon cancer progression.