To explore whether these transcripts are also altered in diseased neural tissue, we analyzed transcriptional data from a large cohort of post-mortem ALS patient spinal cord samples and observed similarly elevated levels of TXNIP and DCLK1 transcripts (Figure 6G), suggesting that ALS involves similar pathways of transcriptional disturbance. Here, DCLK1 is linked to amyotrophic lateral sclerosis.