In prior studies of the small intestine, cell proliferation was the primary force that drove enterocyte migration up the villus, a movement that required integrins.39,40 Moreover, the relationship of talin-1 with both integrins and actin filaments contributes to cell adhesion and ECM traction for movement.17,41 Thus, our data indicates that talin-1 expression in CECs is essential for cell turnover and the movement of proliferating cells up the colonic crypts in a model of infectious colitis. Here, TLN1 is linked to infectious colitis.