This unbiased analysis identified SH2B3 as a potential key driver of hypertension.36 Subsequent studies using mice with genomic excision of exons 2 through 6 of Sh2b3 were performed by Saleh et al. to test whether Sh2b3 deficiency alters BP and end-organ damage in hypertension. The gene discussed is SH2B3; the disease is Hypertension.