This salt retention occurred through enhanced interactions of PDL-1 on distal convoluted tubule cells with PD-1 on CD8+ T cells with resultant increased IFNγ production.28 Thus, the PD-1/PD-L1 pathway may have distinct, context-dependent effects on inflammation and salt retention in the context of hypertension. The gene discussed is CD8A; the disease is Hypertension.