SH2B3 is an intracellular adapter protein that negatively regulates cytokine and growth factor signaling.35 Multiple genome-wide association studies in humans identified a strong association between a missense polymorphism in SH2B3, rs3184504, and hypertension.36, –38 Building on findings from these GWAS studies, Huan T et al. conducted a network analysis combining GWAS results with human whole-blood transcriptomic and molecular interaction networks. The gene discussed is SH2B3; the disease is hypertensive disorder.