IgA nephropathy (IgAN) (also known as Berger disease) is the most common form of glomerular nephropathy, and prognosis is poor.86,87 It occurs when immunoglobulin A (IgA) builds up in the kidneys, progressing to ESKD in almost 50% of the affected cases. This evidence concerns the gene CD79A and IgA glomerulonephritis.