The G1 locus has with two coding variants—rs73885319 (p.S342G) and rs60910145 (p.I384M) in the last exon of APOL1 gene—while the G2 locus is a six base pair deletion close to G1, which removes amino acids N388 and Y389 in the APOL1 gene.41,42 These renal risk variants (RRVs) conferred enhanced innate immunity against African trypanosomes that causes the deadliest form of sleeping sickness. The gene discussed is APOL1; the disease is human African trypanosomiasis.