TNF and neoplasm: An immunosuppressive environment to promote tumor escape is created by enhancing the release of immunosuppressive cytokines, including IL‐5, IL‐8, and IL‐10, from activated immunosuppressive cells (Tregs and MDSCs) and inhibiting the release of immune‐activating cytokines, including IL‐1, TNF‐α/β, and IFN‐γ.70