VEGF creates an immunosuppressive microenvironment through the following three mechanisms: (1) enhancing proliferation of regulatory T cells (Tregs) and myeloid‐derived suppressor cells (MDSCs) to release more immunosuppressive cytokines, (2) preventing T cells from infiltrating tumor tissues, and (3) reducing T‐cell proliferation and activation by suppressing the activation and maturation of dendritic cells (DCs). Here, VEGFA is linked to neoplasm.