Apart from commonly seen TP53, RB1 and PTEN alterations, genomic and transcriptomic investigations have uncovered three specific subtypes LMS that likely develop from distinct lineages of smooth muscle cells: 1) Dedifferentiated LMS with myogenic differentiation and high immune cell infiltration, 2) Tumor arising in the abdomen or extremities with vascular smooth muscle phenotype, low mutational burden, and a better prognosis, and 3) Tumors primarily of gynecological origin with dystrophin alterations (9,10). The gene discussed is TP53; the disease is neoplasm.