TARDBP and amyotrophic lateral sclerosis: Approximately 10% of ALS patients have a known family history of the disease, and variants in several genes such as SOD1, FUS, TARDBP, UBQLN2, PFN1, OPTN, VCP, MATR3, TUBA4A and C9ORF72 have been discovered and account for the majority of familial ALS and 5% of sporadic ALS cases [2, 3, 4, 5, 6, 7, 8, 9, 10, 11].