We validated that a block of the ACE2 surface receptor or inhibition of TMPRSS2 surface serine protease via camostat mesylate decreased viral entry into epithelial cells, underpinning the ability of SARS-CoV-2 to utilize the TMPRSS2-dependent cell-surface entry route to establish infection of intestinal epithelial cells (Figure 2(B)). Here, TMPRSS2 is linked to infection.